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The development of irreversible pathologies in the human body requires a significant amount of oxygen (the enzyme NADP-H is an immune reaction of phagocytes), as well as a stock of available oxygen for ROS synthesis.
To mobilise the required dissolved O2 and activate ROS synthesis, an oxygen donor must be applied. Oxygen adsorbed on the surface of the compositions of the formulation ingredients is a suitable therapeutic donor source. NADPH-oxidase (NOX) is one of the major sources of cellular reactive oxygen species (ROS) and is formed by catalysis.
Role of ROS - targeting reaches the site of infectious infiammation and interacts with NADP-H of immune cells of phagocytes and macrophages, causing numerous cytomorphological changes in them, thereby triggering apoptotic or necrotic type of pathogenic cell death.
ROS synthesis - toxic to cellular pathogens, destroys pathogenic agents and molecules. At the same time, healthy cells are not damaged because, unlike virus-infected cells, healthy cells have antioxidant enzyme systems.
ROS synthesis in the body - targeting, therapeutic ideal safety, is due to the localisation of the infiammatory process induced, provoked by macrophages in response to pathogens of viral etiology (SARS Cov-2 and their subsequent mutations).
Target penetration into problematic cells of the organism, reaching the site of infiammation of infectious nature is due to the immune reaction, i.e. increase (multiple of 10÷15 times) of oxygen demand in the foci of infiammation on the enzyme complex NADPH-oxidase.
Which catalyses the formation of superoxide free radical by transferring one electron to oxygen from NADPH, playing an important role in immunity, cell signalling (NADPH + 2O2 <--> NADP+ + 2O2- + H+)
In the electron transport chain, during the reaction of oxygen with reducing compounds NADH, the redox energy stimulates the synthesis of adenosine triphosphate (ATP), which is the main source of energy for living cells.
To know more about the selected nosology(-ies), we recommend that you visit the Application Form section, where you can learn more about nosologies, disease groups and subgroups. You will also learn about CTA files and technology transfer, routes of drug administration, registration statuses, and other aspects of the service by filling in the sections of interest in an interactive form. Once you have completed the relevant sections, you will receive personalized offers and files with detailed information on the readiness of the technology. The aim is for the Applicant’s company to make a decision proceeding to Step 1 - 'Registration'.
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